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Other specific KRAS (G12C) inhibitors from other companies are also under investigation in clinical trials, including LY3499446, D-1553, and ARS-3248/JNJ-74699157, which are next-generation ARS-1620 inhibitors (NCT04006301, NCT04165031, and NCT04585035) (Table 2)

V.ZaitsevB

Abstract Gastric cancer is one of the top causes of cancer-related death globally

It binds to drug metabolites, alcohol byproducts (acetaldehyde), heavy metals, environmental pollutants, and other toxins through a process called glutathione conjugation

A phase 2a placebo-controlled trial in 137 early and untreated PD subjects has recently reported satisfactory safety, clinical (MDS-UPDRS part II) and biomarker (quantitative a-synuclein immunohistochemistry) outcomes trending in favour of risvodetinib but with mostly statistically non-significant differences from placebo [204]